14th September 2017 – 6th Annual St Vincent’s Precinct PostDoc Symposium
Registration 8-9 am
Session 1 9-10.30 am
9-9.15 am Opening by Prof Anna DeFazio and PDDC co-chairs Dr Emily Edwards and Dr David Hermann
9.15-9.45 am Oral Talks (2x15min) Chair: Dr Brigid O’Gorman and Dr Nathan Zammit
9.15-9.30 am Hongjun Shi. NAD deficiency causes multiple congenital malformations that are potentially preventable
by niacin supplementation.
9.30-9.45 am Tim Peters. A general framework for evaluating cross-platform concordance in genomic studies.
9.45-10.30 am Plenary: Dr Samantha Oakes introduced by Brad Timms (Garvan Research Foundation)
Morning Tea 10.30-11 am
Session 2 11 am-12 pm
11am -12 pm Flash Talks (6x5minutes) Chair: Dr Gonzalo del Monte-Nieto and Dr Jeng Yie Chan
11-11.07 am Rules of engagement for Flash Talks. Dr Gonzalo del Monte-Nieto
11.07-11.14 am Joanna Achinger-Kawecka. Chromosome conformation reveals the regulatory role of
three-dimensional epigenome remodelling in endocrine resistant breast cancer.
11.14-11.21 am Beatriz Perez San Juan. Unravelling the clinical relevance of cell plasticity in breast cancer:
to be or not to be, that is the question?
11.21-11.28 am Liz Caldon. Cdk activity is crucial for the onset of endocrine resistance in breast cancer,
and precedes clonal development.
11.28-11.35 am Saskia Reibe-Pal. Investigating the efficacy of two novel treatment strategies on HCC
development in MUP-uPA mice.
11.25-11.42 am Amy Nicks. Dynamic Expression of mRNAs-lncRNAs-miRNAs Regulates Cardiomyocyte
11.32-11.49 am Amy Nguyen. Importance of patient involvement in mobile health app development.
Lunch: Poster Session 12-1.30 pm
Session 3 1.30-2.45 pm
1.30-2.45 pm Oral Talks (5x15min) Chair: Dr Marcia Munoz and Dr Nenad Bartonicek
1.30-1.45pm Thi Thanh Vu. miR-10a inhibition sensitizes nucleophosmin 1-mutant acute myeloid leukaemia
cells to cytarabine.
1.45-2.00pm Katherine Jackson. Human B cell response to acute Ebola virus infection.
2.00-2.15pm Alvaro Gonzalez-Rajal. Cisplatin resistance in lung adenocarcinoma: a live-imaging approach.
2.15-2.30pm Sally Eaton. Environmentally-induced epigenetic inheritance: mechanisms and mysteries.
2.30-2.45pm Ruth Pidsley. Epigenetic hallmarks of the cancer microenvironment.
Afternoon tea 2.45-3.15 pm
Session 4 3.15-4.45 pm
3.15-3.45 pm Oral Talks (2x15min) Chair: Dr Simon Junankar and Dr Niall Byrne
3.15-3.30pm Melinda Tursky. Preclinical testing of novel therapies for Down Syndrome acute
3.30-3.45pm Marit Hjorth. Skeletal muscle secretory proteins: a link between regular physical
activity and reduced breast cancer risk?
3.45-4.45 pm Plenary: Dr Michael Bowen. Introduced by Dr Emily Edwards
Closing Remarks: PDDC Co-Chairs Dr Emily Edwards and Dr David Hermann
Drinks reception and awards 4.45 pm onwards
15th September 2017 – 25th St Vincent’s Campus Research Symposium
Registration 8-9 am
Session 1 8:45- 10:20 am
8:45-9 am Opening: Prof Anna DeFazio
9:00-9:50 am Oral Talks (5×10 min) Chair: Dr. Christine Shiner
9:00-9:10 am Martin Whitham. Quantitative proteomic analysis of the human extracellular vesicle
proteome reveals a novel mechanism for tissue cross-talk during exercise.
9:10-9:20 am Joanne Reed. Single Cell Analysis of Self-reactive Rogue B-cell Clones in Autoimmune Disease.
9:20-9:30 am Niall Byrne. RANKL-induced bone remodelling controls prostate cancer cell dormancy
in an ex vivo calvaria model.
9:30-9:40 am Maria Findeisen. Generation and characterization of IC7 transgenic mice.
9:40-9:50 am David Croucher. Heterogeneity in the single-cell signalling response underlies innate
chemoresistance in neuroblastoma.
9:50-10:20 am Plenary: Prof Kathryn North (Murdoch Children’s Research Institute)
Morning Tea 10:20-11 am
Session 2 11 am-12:30 pm
11:00-11:50 am Oral Talks (5x10min) Chair: Dr. Eva Novoa
11:00-11:10 pm Gonzalo del Monte-Nieto. Extracellular Matrix Dynamics Reveals the Building Plan
for Cardiac Trabeculation.
11:10-11:20 pm Jennifer Massey. Autologous haematopoietic stem cell transplantation (aHSCT) in
multiple sclerosis (MS) a phase II trial.
11:20-11:30 pm Yanchuan Shi (Yan). Inhibition of Y1 receptor signaling improves islet transplant outcome.
11:30-11:40 pm Madeleine Wheatley. Carfilzomib treatment targets both dormant and actively growing
cells whilst preventing myeloma induced bone loss.
11:40-11:50 pm Inken G. Martin. A zebrafish model of a human titin-truncating mutation exhibits spontaneous
dilated cardiomyopathy and impaired tolerance to hemodynamic volume load.
11:50-12:30 am Fast Forward Session (12×3 min) Chair: Dr. Thomas Cox
11:50-11:53 am Mark Cowley. Translating cancer genomics to the clinic, for advanced childhood and rare adult
11:53-11:56 am James Conway. Dual FLIM/PLIM imaging identifies hypoxic regions resistant to PI3K-pathway
targeted therapies in pancreatic cancer.
11:56-11:59 am Julie Moreau. Gene-Environment interactions cause Congenital Heart Disease.
11:59-12:02 am Thao Phuong Ho-Le. Genetic Profiling Predicts Bone Loss and Bone Mineral Density.
12:02-12:05 am Kristen Perry. Live cell imaging approaches to quantify the effect of bisphosphonate on
macrophage morphology, polarisation and migration.
12:05-12:08 am Thomas Steward. Results of a 10-year follow-up study of botulinum toxin A therapy for
primary axillary hyperhidrosis in Australia.
12:08-12:11 am Simon Junankar. Establishing a DNA barcoding approach to track how the immune system
and immunotherapies regulate metastatic breast cancer growth at the clonal level.
12:11-12:14 am Pietro Ridone. Human PIEZO1 membrane localization and gating kinetics are modulated by
12:14-12:17 am Kendelle Murphy. Transient tissue ‘priming’ via FAK inhibition to impair pancreatic ductal
adenocarcinoma (PDAC) progression and improve sensitivity to gemcitabine/Abraxane.
12:17-12:20 am Ann-Kristin Altekoester. Discovery of NkxUS, a novel heart associated lncRNA.
12:20-12:23 am Oliver Skinner. Increased IL-1Î² release in a model of mevalonate kinase deficiency is
12:23-12:26 am Katherine Tonks. Foot Clinic on a shoestring.
Lunch: Poster Session 12:30-2:10 pm (Poster Marking 12.50-2.10 pm)
Session 3 2:10-3:50 pm
2:10-3:10 pm Rising Stars (3×20 min) Chair: Dr. Samantha Oakes
2:10-2:30 pm Christine Shiner (AMR). Technology in rehabilitation – exploring novel ways to improve
patient safety, education and rehabilitation outcomes
2:30-2:50 pm Eva Novoa (Garvan). Genome-wide in vivo mRNA structure dynamics identifies RNA
remodelers and functional elements during vertebrate embryogenesis.
2:50-3:10 pm Alastair Stewart (Victor Chang). Cryo-EM studies of E. coli ATP synthase.
3:10-3:30 pm Orals (2×10 min) Chair: Dr. Alistair Stewart
3:10-3:20 pm Kelly Coughlan. International nursing care translation: The Quality in Acute Stroke
Care (QASC) implementation program.
3:20-3:30 pm Simeon Dale. Improving Triage, Treatment and Transfer of patients with stroke in
Emergency Departments: The T3 Trial.
3:30-4 pm Plenary: Prof Doug Hilton (Walter and Eliza Hall Institute)
Break 4-4:10 pm
Panel Discussion (Theme: Precision Medicine) 4:10-4:55 pm
Panel Chair: Prof David Thomas